When using radiation sterilization, medical device and pharmaceutical companies are faced with the choiceof gamma, electron-beam, or x-ray sources. But which one to choose? While it may be tempting to go withthe familiar option, each of these techniques has its own benefits that might make it the ideal choicefor a particular product. With a new simulation approach, we can guide companies toward the most efficient, cost-effective, and reliable sterilization method for their product.