Secant Group announces development of technology to advance cardiovascular regenerative medicine

Telford, PA, January 16, 2018 - Secant Group, in partnership with its sister company SanaVita Medical, announce game changing technology to advance cardiovascular regenerative medicine with the development of a synthetic, small bore, vessel that encourages endogenous regeneration and new vessel formation. The technology is based on the company’s sophisticated textile forming capabilities that can produce a hollow lumen construct that is infused with Secant’s proprietary Regenerez® bioresorbable polymer technology. The new small bore vessel supports the regeneration of new vascular tissue structures without the need for cell seeding or biologic growth promoters.

In situ vascular regeneration, along with the elastomeric and immunomodulatory properties of the synthetic vessel, could solve the problems of vascular harvesting and the non-resorbable synthetic graft compliance mismatching seen with the current technology available for surgeons today. These regenerative grafts will offer unprecedented benefits for coronary artery bypass surgery, peripheral vascular disease, and renal disease treatments.

Secant has produced small bore grafts with lumen diameters down to 500 m, closely matching the range of human vessels. Jeff Robertson, President of Secant Group, explains, “By combining our textile manufacturing and biomaterials capability, this small bore graft would provide similar compliance as native vasculature, enabling a seamless connection between graft and vessel. A Regenerez based graft would stimulate regenerative vessel healing and cell growth, eventually degrading to leave only the native tissue behind, creating a new vessel.”

Devices that currently dominate the cardiovascular graft replacement market have numerous limitations including compliance mismatch, low patency rates, calcification, a risk of infection and lack of tissue regeneration capability. The Secant small bore graft addresses many of these limitations. Early pre-clinical studies have confirmed that Regenerez grafts are non-thrombogenic, did not show occlusion and provide excellent suturability. Secant is continuing the development of small bore grafts in collaboration with a leading heart and vascular research university. Secant Group is currently looking for medical device partners to progress this exciting new technology through clinical trials and commercialization.

About Secant Group, LLC:

Secant Group engineers medical textiles and biomedical structures that enable repair, recovery, and regeneration of the human body. Using advanced polymers, metals and composites, Secant Group partners with OEMs to design, develop, and manufacture implantable structures for medical devices that improve quality of life for patients.

About SanaVita:

SanaVita Medical® is a fully integrated contract manufacturer for medical devices. With expertise in advanced biomaterials and textile engineering, SanaVita can solve complex technical challenges and provide unique solutions that improve patient outcomes. In partnership with Secant Group, SanaVita is exclusively positioned to bridge the gap between device design and manufacturing throughout the device development process.

Contact Information:
Diane Reitter – Director, Marketing
Email: [email protected] Phone: 215-257-8680 (X130)

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